Engineering the Therapeutics of the Future

Co-Located with Molecular Med TRI-CON Asia

May 28-31, 2013
Marina Bay Sands, Singapore

Co-Located Bio-IT World Asia

 

Accompanying the ever growing genetic and proteomic biomarker research, molecular diagnostic tools are playing more and more important roles in the clinic, as well as the pharmaceutical development process. This track will feature novel tools and analytics approaches that facilitate personalized diagnostics assay development.

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Thursday, May 30

13:00 Registration


PRENATAL MOLECULAR DIAGNOSTICS  

13:40 Chairperson’s Remarks

Hao Sun, Ph.D., Assistant Professor, Department of Chemical Pathology; Director, Biomedical Computing Centre, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong

13:50 The Trend of Non-Invasive Prenatal Tests (NIPT)

Daixing ZhouDaixing Zhou, Ph.D., CEO, Berry Genomics Co., Ltd.

NIPT is rapidly transforming the field of prenatal screening and diagnosis. It is far more accurate than serum screening and more scalable than invasive diagnosis. Like other technologies, it comes with shortcomings. This talk will present the pros and cons of NIPT based on clinical practice in China and discuss the future directions.

 

14:20 FetalQuant: Deducing Fractional Fetal DNA Concentration from Massively Parallel Sequencing of DNA in Maternal Plasma

Hao SunHao Sun, Ph.D., Assistant Professor, Department of Chemical Pathology; Director, Biomedical Computing Centre, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong

The fractional fetal DNA concentration is one of the critical parameters for non-invasive prenatal diagnosis based on the analysis of DNA in maternal plasma. Massively parallel sequencing (MPS) of DNA in maternal plasma has been demonstrated to be a powerful tool for the non-invasive prenatal diagnosis of fetal chromosomal aneuploidies. We will discuss a novel program, FetalQuant, which utilizes the maximum likelihood to estimate the fractional fetal DNA concentration directly from targeted MPS of DNA in maternal plasma non-invasively.

14:50 Q&A with Session Speakers

15:00 Refreshment Break in the Exhibit Hall with Poster Viewing


INFECTIOUS DISEASE DIAGNOSTICS  

15:40 Development of Novel Serological Tests for Biosafety Level 4 (BSL4) Agents

Linfa WangLinfa Wang, Ph.D., FTSE, Professor & Director, Program in Emerging Infectious Disease, Duke-NUS Graduate Medical School

Biosafety level 4 (BSL4) agents (such as Ebola virus, Hendra and Nipah viruses) pose a great threat to human health as a result of either natural zoonotic transmission or intentional release. Current serological diagnosis requires the use of live viruses within a BSL4 facility, which greatly restricted their application in most countries or regions. We have developed surrogate testes that can be conducted in a standard BSL2 lab, significantly enhancing their accessibility and utility in most labs around the world.

16:10 Rapid and Sensitive Detection of Highly Pathogenic Influenza H5N1 Virus

Toshihisa IshikawaToshihisa Ishikawa, Ph.D., Professor of Biochemistry, Molecular Biology and Pharmacogenomics, Omics Science Center, RIKEN Yokohama Institute

The possibility of human-to-human transmission of highly pathogenic avian influenza A(H5N1) viruses is becoming a fear for human health and society. To address the medical need for rapid diagnosis, we have recently developed a new assay method to rapidly detect influenza A(H5N1) virus from patient swab samples. The new assay method comprises both reverse transcriptase (RT) and isothermal DNA amplification reactions in one step. Therefore, the RT-SmartAmp assay method requires neither RNA extraction nor PCR reaction. Furthermore, we have designed a small-sized visual detection device that enables on-site detection of influenza A(H5N1)virus.

16:40 Development and Application of “Bacterial Counter” - Rapid Oral Bacteria Detection Device Based on Dielectrophoretic Impedance Measurement Method

Ryo HamadaRyo Hamada, Ph.D., Panasonic Healthcare Co., Ltd.

We have developed a bacteria detection device, “Bacterial counter”, based on dielectrophoretic impedance measurement (DEPIM) method for rapid evaluation of oral hygiene. The authors integrated a electrode chip on which bacteria were captured by dielectrophoresis (DEP), an AC source to induce DEP, and an impedance measurement circuit to a portable instrument that enables rapid and automated inspection in hospitals and clinics. Here, overview of DEPIM method, optimization of DEPIM condition for oral samples are presented. Several clinical data using “Bacterial counter” and suggestion of the possibility of this method for the future are also provided.

17:10 Dinner Short Course Registration

17:30 – 19:30 Dinner Short Course (Separate Registration Required)



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